Effect of Model Traumatic Injury on Hepatic Drug-metabolizing Enzymes

Abstract
Abdominal aorta ligation in rats was a suitable model traumatic injury for the study of effect of trauma on drug-metabolizing enzymes. This procedure resulted in a rapid decrease in cytochrome P-450, and mixed function amine oxidase activities. Recovery of mixed function amine oxidase activity was slower than recovery of cytochrome P-450 activity.