Resistance Factor-Mediated Spectinomycin Resistance
- 1 January 1970
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 1 (1), 120-127
- https://doi.org/10.1128/iai.1.1.120-127.1970
Abstract
Of 100 natural isolates of drug-resistant enteric bacteria, 51 were resistant to spectinomycin (Spc) and 46 contained transferable R factors mediating Spc resistance. All SpcR R factors mediated streptomycin and bluensomycin resistance and were fi+ type. Extracts of R-SpcR strains adenylated Spc, dihydrospectinomycin, actinamine, streptomycin, and bluensomycin in vitro in the presence of adenosine triphosphate and Mg++. Results of genetic and biochemical studies support the hypothesis that these reactions are mediated by a single enzyme.Keywords
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