In an acute migraine clinic, patients were all treated with metoclopramide 10 mg i.m. and diazepam 5 mg p.o. In addition, 435 received acetylsalicylic acid 1,000 mg and 254 paracetamol (acetaminophen) 1,000 mg p.o. A computer analysis revealed the two groups of patients to be not statistically significantly different. In fact they were almost identical with respect to a large number of clinical parameters. The treatment results in the two groups were identical. The present study indicates that the two drugs are equipotent in the treatment of the acute migraine attack.