THE TOXIC FACTORS IN EXPERIMENTAL TRAUMATIC SHOCK. II. STUDIES ON ELECTROLYTE AND WATER BALANCE IN SHOCK 1

Abstract

Extracellular space measurements and tissue and blood electrolyte detns. were made on dogs shocked by hemorrhage and by 3 procedures producing trauma or ischemia. No evidence was found of significant changes in the extracellular space of the whole body with these procedures except for that which occurred locally in traumatized areas. Plasma Na and Cl did not show any significant changes; increase in plasma K terminally, as reported by others, was confirmed. Tissue analyses showed marked loss of K and gain of Na by muscles which had been directly traumatized or tied to produce ischemia. This change was probably due in part to local intra- or extra-cellular edema and in part to net loss of K from injured cells.