Gonadotropin Excretion in Normal Men and Women and Cases of Hysterectomy, Menopause, Migraine, Epilepsy and Eunuchoidism

Abstract

Gonadotrophin was '' concentrated from entire 1st morning specimen of urine, by the alc. precipitation method. Toxic salts were removed by dialysis or by several washings with 80% alc. The entire amt. was injected in one 21 day old rat, in 9 injs. The uterine wt. was used as an index, unless over 150 mg., when ovarian wts. were also recorded. A normal young showed a single peak of urinary gonadotrophin between menses, and another showed 2 peaks. A hysterectomized had normal single and double peaks in corresponding periods. A young with premature menopause showed a constant high urinary titer, which was reduced in proportion to the dosage of estrogen, suggesting a means of estrogen assay in the human. A normal [male] had no appreciable secretion; 1 with migraine showed high and irregular excretion which disappeared with successful dietary treatment. One epileptic had a high excretion but 2 others had none. A eunuchoid [male] showed no excretion.