FAMILIAL OCCURRENCE OF CEREBRAL GIGANTISM, SOTOS' SYNDROME

Abstract

Since the original description of cerebral gigantism, about 85 cases were reported. Four papers comment on familial occurrence but never in parents and their children. The syndrome was described in a mother and her child, which, together with facts pointing towards prenatal etiology, such as excessive birthweight, striking mutual resemblance and abnormal dermatoglyphics, points to a genetic defect. There was normal serum somatomedin and serum prolactin.