Prevention of Salicylate Teratogenicity in Immobilized Rats by Certain Central Nervous System Depressants.

Abstract

Prior treatment of pregnant rats with the central nervous system depressants, sodium pentobarbital or chlorpromazine, prevents the augmentation by maternal immobilization of the maternal morbidity and teratogenic action induced by sodium salicylate on the tenth day of gestation. The prevention by either central depressant of the production of congenital malformations in immobilized animals given otherwise non-teratogenic doses of salicylate appears to be mediated through the maternal central nervous system.