THE ANTIDIURETIC HORMONE IN THE URINE IN EXPERIMENTAL AND CLINICAL HYPERTENSION1

Abstract

Hypertension, experimentally induced in laboratory animals as well as the clinical form of this disorder, is accompanied by certain changes in salt and water metabolism (Grollman, 1947). These observations suggested the desirability of a study of the excretion of the antidiuretic principle in the urine in various forms of hypertension in order to determine to what extent the altered salt and water metabolism in hypertension is accompanied by changes in the antidiuretic activity of the urine. methods The procedures outlined in the preceding paper were utilized for the determination of the antidiuretic content of the urine. Twenty-four hour specimens of urine were collected from a group of patients suffering from hypertensive cardiovascular disease who had been followed in the hypertension clinic of the Parkland Hospital. Specimens were also collected from a series of rats and dogs in which chronic hypertension had been induced at least 6 months previously by the application of a figure-of-eight ligature to the right kidney and ablation of the left kidney (Grollman, 1944).