Identification of the GABAA receptor subtype mRNA in human pancreatic tissue
- 13 June 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 346 (2-3), 257-262
- https://doi.org/10.1016/0014-5793(94)00485-4
Abstract
Evidence suggests a physiological role of the GABAA receptor in the pancreas. Clinically, an autoimmune reaction involving the GABA biosynthesizing enzyme, glutamic acid decarboxylase has been implicated in the development of insulin-dependent diabetes mellitus. To determine the subtypes of GABAA receptor expressed in human pancreas, we analyzed, with the use of the reverse-transcription/polymerase chain reaction technique human pancreatic tissue for the presence of GABAA receptor subunits alpha 1-6, beta 1-3, and gamma 1-2 transcripts. Unlike brain tissue, pancreatic tissue only expresses the alpha 2, beta 3 and gamma 1 subunits. Our results provide evidence of a specific GABAA receptor subtype expressed in human pancreatic tissue.Keywords
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