Cell-mediated immunity: differential maturation of mixed leukocyte reaction and cell-mediated lympholysis.
Open Access
- 1 June 1975
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 142 (5), 1301-1305
- https://doi.org/10.1084/jem.142.5.1301
Abstract
While spleen cells from neonatal B10 (H-2b) are reactive (proliferate) in one-way mixed leukocyte culture, cell-mediated lympholysis reactivity does not arise until 7 days of age. When B10 cells are sensitized to B10.D2 (H-2d), cross-killing of third-party B10.BR (H-2k) target is always lower than the specific killing of B10.D2 targets and is not demonstrable until 27 days after birth.Keywords
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