The effects of colcemid on hematopoiesis in the mouse.
Open Access
- 1 November 1976
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 58 (5), 1280-1285
- https://doi.org/10.1172/jci108583
Abstract
Colcemid was found to induce a dose and schedule dependent marrow magakaryocytosis and peripheral thrombocytosis. The response could be divided into early and late components. The early component appears to have been due to a direct stimulatory effect, probably by enhancement of endoreduplication in metaphase arrested megakaryocyte precursors. The ealy stimulatory response was blunted on toxic drug schedules. In contrast, the late component of the thrombopoietic response was demonstrated best on the most toxic drug schedules. It coincided temporally with the reactive restoration of the mononuclear marrow and blood cell elements, respectively. Thus, the late component appears to be a nonspecific rebound phenomenon. On comparing the thrombopoietic properties of Colcemid with those of the vinca alkaloids in experimental systems, the former appears to have a more favorable therapeutic index. The data suggest that colchicine and its derivatives may be useful agents in the treatment of clinical thrombocytopenic states.Keywords
This publication has 27 references indexed in Scilit:
- THE EFFECTS OF COLCEMID ON MOUSE BONE MARROWCell Proliferation, 1976
- KINETIC‐MICROARCHITECTURAL CORRELATIONS IN THE BONE MARROW OF THE MOUSECell Proliferation, 1975
- Effects of Vincristine on Normal and Stimulated Megakaryocytopoiesis in the RatBritish Journal of Haematology, 1975
- Experimental evolution of cell populations of chinese hamster treated with colchicine. induction of high degree of ploidy and a phase-specific lethal effectInternational Journal of Cancer, 1972
- Effect of Vincristine on Platelet Production in MiceBritish Journal of Haematology, 1972
- Vincristine-Induced Thrombocytosis Studied with 75Se SelenomethionineActa Haematologica, 1972
- Clinical Experiences with Cytotoxic Immunosuppressive Treatment of Idiopathic Thrombocytopenic PurpuraActa Haematologica, 1971
- Chromosome polyploidization in human leukocyte cultures treated with streptonigrin and cyclophosphamideCancer, 1967
- Chronic idiopathic thrombocytopenia; treatment with prednisone, 6-mercaptopurine, vincristine, and fresh plasma transfusionsThe Journal of Pediatrics, 1966
- FEULGEN-DNA VALUES IN MEGAKARYOCYTESThe Journal of cell biology, 1964