A False Positive HIV Antibody Reaction Due to Transfusion-Induced HLA-DR4 Sensitization
- 1 June 1989
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 320 (22), 1495-1496
- https://doi.org/10.1056/nejm198906013202215
Abstract
To the Editor: Enzyme-linked immunosorbent assays (ELISAs) for serum antibodies to the human immunodeficiency virus (HIV) may give false positive results in low-risk groups.1 , 2 HLA antigens are present in some HIV ELISA kits,3 , 5 and antibodies against HLA Class II antigens occur in some subjects with false positive ELISAs.6 , 7 However, serial studies have not been done to establish a causal relation between these findings. We describe a patient with acute leukemia in whom both antibodies against HLA-DR4 and a false positive HIV ELISA transiently occurred while he was receiving red-cell and platelet transfusions.Screening for HIV antibody was performed with an . . .Keywords
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