Pharmacokinetics of Lidocaine in Fetal and Neonatal Lambs and Adult Sheep
Open Access
- 1 May 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 50 (5), 431-436
- https://doi.org/10.1097/00000542-197905000-00011
Abstract
The pharmacokinetics of lidocaine were studied in fetal and neonatal lambs and in pregnant and nonpregnant adult sheep. Catheters were implanted in the femoral vessels and in the urinary bladders of animals prepared for chronic study. Lidocaine, 5-10 mg/kg, was injected i.v. either into the fetus or newborn lamb or into nonpregnant adult sheep. Serial samples of arterial blood and urine were obtained over 4 h and analyzed for unchanged lidocaine using a gas chromatographic technique. The elimination half-lives of lidocaine in the bloods of nonpregnant ewe, neonate and fetus were 31, 51 and 33 min, respectively. Total-body clearances in the neonate and adult were 53 and 41 ml/min per kg. The metabolic clearances of lidocaine were the same in both and approximated hepatic blood flow. Renal clearance was greater in the neonate, which was attributed to differences in urinary pH values and extents of protein binding. Despite differences in half-lives, the newborn lamb is as capable as the adult of clearing lidocaine.This publication has 2 references indexed in Scilit:
- The Determination of Lidocaine and Prilocaine in Whole Blood by Gas ChromatographyAnesthesiology, 1968
- OBSERVATIONS ON THE GROWTH RATES AND ORGAN WEIGHTS OF FETAL SHEEP AT ALTITUDE AND SEA LEVELQuarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1962