Nuclear Inclusions in Malignant Gliomas
- 1 September 1965
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 13 (3), 287-296
- https://doi.org/10.1001/archneur.1965.00470030067006
Abstract
IN 1932 Russell1 observed that round or oval eosinophilic intranuclear inclusions occurred in 63 of 192 gliomas, with the highest incidence (61%) being in glioblastoma multiforme. The inclusions were 3μ to 17.5μ in diameter, homogeneous or finely granular, and sharply outlined by a thin basophilic "capsule." Nuclei with inclusions were generally enlarged and frequently hyperchromatic. It was thought that the inclusions resembled those occurring in virus-infected cells and were compatible with being the result of viral activity. Although the author suggested that the inclusions could be distinguished from nuclear folds containing cytoplasm, it is noteworthy that the staining reactions of the former were similar to those expected of cytoplasm. Subsequently Wolf and Orton2 reported the presence of morphologically similar inclusions in 16 of 33 glioblastomas and in other forms of intracranial tumors. Again the resemblance to viral inclusions was commented upon, and it was suggestedThis publication has 4 references indexed in Scilit:
- ELECTRON MICROSCOPIC STUDIES OF NUCLEAR INCLUSIONS IN MENINGIOMAS1964
- FUNCTIONAL EVIDENCE FOR THE EXISTENCE OF A THIRD CELL TYPE IN THE RENAL GLOMERULUSThe Journal of cell biology, 1962
- An Electron Microscope Study of Intranuclear Inclusions in Mouse Liver and HepatomaThe Journal of cell biology, 1959
- INTRANUCLEAR INCLUSION BODIES IN BRAIN TUMOURSThe Lancet, 1933