Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF
- 17 March 1995
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 267 (5204), 1662-1666
- https://doi.org/10.1126/science.7886458
Abstract
During the development of the visual system of higher mammals, axons from the lateral geniculate nucleus (LGN) become segregated into eye-specific patches (the ocular dominance columns) within their target, layer 4 of the primary visual cortex. This occurs as a consequence of activity-dependent synaptic competition between axons representing the two eyes. The possibility that this competition could be mediated through neurotrophin-receptor interactions was tested. Infusion of neurotrophin-4/5 (NT-4/5) or brain-derived neurotrophic factor (BDNF) into cat primary visual cortex inhibited column formation within the immediate vicinity of the infusion site but not elsewhere in the visual cortex. Infusion of nerve growth factor, neurotrophin 3 (NT-3), or vehicle solution did not affect column formation. These observations implicate TrkB, the common receptor for BDNF and NT-4/5, in the segregation of LGN axons into ocular dominance columns in layer 4. Moreover, they suggest that in addition to their better known roles in the prevention of cell death, neurotrophins may also mediate the activity-dependent control of axonal branching during development of the central nervous system.Keywords
This publication has 44 references indexed in Scilit:
- Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesionNature, 1994
- Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNFNature, 1993
- Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrainNeuroReport, 1991
- Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesisNeuron, 1991
- BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGFNeuron, 1991
- Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNFScience, 1990
- Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron populationJournal of Comparative Neurology, 1989
- Modulation of visual cortical plasticity by acetylcholine and noradrenalineNature, 1986
- Ocular dominance columns and their development in layer IV of the cat's visual cortex: A quantitative studyJournal of Comparative Neurology, 1978
- The pattern of ocular dominance columns in macaque visual cortex revealed by a reduced silver stainJournal of Comparative Neurology, 1975