The pH-dependence of chloroquine uptake by phosphatidylcholine vesicles
- 1 October 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 38 (10), 761-763
- https://doi.org/10.1111/j.2042-7158.1986.tb04486.x
Abstract
The pH-dependence of chloroquine uptake by phosphatidylcholine bilayered vesicles was investigated to examine the relative affinity of ionized and un-ionized chloroquine species to membrane bilayers. The results suggest that the neutral species and monocation are taken up by the bilayers but only the un-ionized species interacts significantly with the hydrocarbon interior.This publication has 9 references indexed in Scilit:
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