Tolerance Induced by Thymic Epithelial Grafts in Birds
- 28 August 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 237 (4818), 1032-1035
- https://doi.org/10.1126/science.3616623
Abstract
Grafts of the anterior limb bud introduced at embryonic day 4 between histoincompatible chick embryos were subject to chronic, mild rejection beginning from several weeks to several months after birth. In contrast, quail wing buds similarly grafted into chickens started to be rejected at the first or second week after birth and finally autoamputated. Embryonic thymus epithelium from donor quail (before it had been colonized by hemopoietic cells) was grafted into chicks. A chimeric thymic epithelial stroma was generated in which the lymphocytes of the chick acquired the capacity to recognize the grafted limb as self either permanently or for a protracted period of time. In such thymic chimeras the grafted wings were not rejected.This publication has 46 references indexed in Scilit:
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