Differential Removal of Strontium 85 and Calcium 45 from Rat Skeleton By Peritoneal Lavage

Abstract

1) A simple technic has been described for removal of electrolytes from the rat by peritoneal lavage. From comparisons of strontium/calcium ratios in lavage solutions and bones of nephrectomized rats it is estimated that strontium was preferentially released from bone by a factor of 1.3 over calcium. 2) It was calculated that strontium preferentially entered bone from blood by a factor of 1.3 to 1.6. The differential removal of the 2 elements from the intact rat was shown to be due mainly to renal function. Eight hours of peritoneal lavage removed about 5% of the Sr∗ that had been deposited for 24 hours but only about 0.6% of that deposited for 8 days.