Persistent Infection of Human Cells (HeLa) with Adenovirus Type 12.

Abstract

Summary The establishment of an adeno-virus type 12 cell carrier system is described. Characteristics of the carrier cultures include an initial dependence on inhibitor or antibody in human serum, an enhanced rate of growth after the fifth day as compared to uninfected cells, a relatively high percentage of infected cells, but a low percentage of detectable virus yielding cells, and relative resistance to super-infection. Secondary mechanisms responsible for the carrier state may include the selection of resistant cells, interference by non-infectious virus and inter-feron.