THERAPEUTIC EFFECT OF LEO 1031, AN ALKYLATING CORTICOSTEROID ESTER, IN LYMPHOPROLIFERATIVE DISORDERS

Abstract

Leo 1031, a chlorambucil ester of pred nisolone, has been administered orally to 15 patients with chronic lymphocytic leukaemia (CLL) continuously for 1–29 months (mean 12.5). Seven patients were previously untreated and eight had been treated with prednisolone, radiotherapy and/or alkylating agents. The initial daily dose was generally 8–16 mg and the maintenance dose was 6–8 mg. Allopurinol was given concurrently. In 14 of 15 patients a reduction of the leucocyte count was observed and a reduction, in most instances, of lymphadenopathy or splenomegaly, or both. In seven patients the Hb concentration was improved. Significant toxic effects on bone marrow function have been observed in one patient. Two patients developed urticaria. Our study suggests that the drug is effective in the treatment of CLL.