Elevation of Certain Plasma Proteins in Man Following Estrogen Administration: A Dose-Response Relationship

Abstract

The degree of elevation of the plasma concentrations of corticosteroid-binding globulin (CBG), [beta]-glucuronidase and ceruloplasmin in response to estrogen administration was shown to be related, within limits, to the dose of estrogen. Three estrogenic materials [long dash] Premarin, diethylstilbestrol and ethinylestradiol [long dash] were tested. The highest dose-response correlation was observed with CGB and the lowest with ceruloplasmin. Ratios of potency for Premarin, diethylstilbestrol and ethinylestradiol were found to be 1:13 - 15:100 - 400, respectively. Women were found to show a significantly greater CBG rise than men after 7 days of 5 mg of diethylstilbestrol. The maximal rise of plasma CBG was found after 14 days of 5 mg of diethylstilbestrol daily. The response in 7 days was 67% of maximum.