ADP-ribosyl transferase, rearrangement of DNA, and cell differentiation
Open Access
- 1 September 1983
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 3 (9), 815-830
- https://doi.org/10.1007/bf01133780
Abstract
Cell differentiation is the process by which genetic information is selectively expressed to produce cells with various morphologies and functions. The integrated changes necessary for this fundamentally important process have recently been the subject of intense study. This review will summarize data from several laboratories correlating differentiation with the activity of the enzyme ADP-ribosyl transferase and with changes in single-strand DNA breaks in various diverse eukaryotic systems. We will then discuss the implications of these observations for differentiation in general, including the possibility that rearrangement of geneticmaterialisa widespread mechanism for controlling gene expression.This publication has 76 references indexed in Scilit:
- Building for EarthquakesScience, 2004
- NAD turnover during early development of Xenopus laevisBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1983
- Enhanced chondrocytic differentiation in chick limb bud cell cultures by inhibitors of poly(ADP-ribose) synthetaseBiochemical and Biophysical Research Communications, 1983
- Abnormal NAD+ levels in cells from patients with Fanconi's anaemiaNature, 1982
- Therapeutic promise maintainedImmunology Today, 1982
- Involvement of poly(ADP-ribose) metabolism in induction of differentiation of HL-60 promyelocytic leukemia cellsBiochemical and Biophysical Research Communications, 1982
- Inhibition of (ADP-ribose)n biosynthesis retards DNA repair but does not inhibit DNA repair synthesisBiochemical and Biophysical Research Communications, 1981
- Inhibitors of poly(ADP-ribose) polymerase enhance unscheduled DNA synthesis in human peripheral lymphocytesBiochemical and Biophysical Research Communications, 1981
- Isoproterenol-induced ADP-ribosylation of a single plasma membrane protein of cultured differentiated RL-PR-C hepatocytesBiochemical and Biophysical Research Communications, 1981
- Transposable genetic elements as agents of gene instability and chromosomal rearrangementsNature, 1977