STUDIES ON THE EFFECTS OF d -AMINO ACIDS ON BRUCELLA ABORTUS
- 1 February 1952
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 63 (2), 263-268
- https://doi.org/10.1128/jb.63.2.263-268.1952
Abstract
The unnatural isomers and the racemates of 10 amino acids were studied on 3 strains of B. abortus; one strain required added CO2 and the other 2 did not. All the DL-amino acids tested demonstrated inhibitory effect when the brucella were grown under optimal conditions. The added CO2-requiring strain was inhibited to a greater extent when CO2 was added in suboptimal amts. DL-phenylalanine and DL-methionine are the most effective inhibitors, while DL-lysine was found to be the least effective of the 10 amino acids tested. The data showed that the D-forms exhibited bactericidal, as well as bacteriostatic, effect in concns. in which the L-forms have no demonstrable inhibition. The possible modes of action are discussed.Keywords
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