Aggressive non-hodgkin's lymphoma: long term results of full dose CHOP chemotherapy, and analysis of prognostic determinant

Abstract

Prognostic factors for complete remission rate (CR), duration of remission and survival were analysed in a series of 150 patients with intermediate (diffuse large-cell) and high grade non-Hodgkin's lymphoma treated with full doses of CHOP over a 10 year period with a minimum follow-up of 5 years. The two factors which significantly predicted for CR were normal LDH level and absence of bone marrow involvement. For duration of CR. the only significant factor was disease bulk, while for duration of survival age, LDH and B-symptoms were all significant. 48 patients were alive and in CR at 7 years or more with a projected long term (10 years or >) overall survival of 55 percent.