Observations concerning positive serologic reactions for rheumatoid factor in certain patients with sarcoidosis and other hyperglobulinemic states

Abstract

Positive latex fixation tests were observed in relation to sarcoidosis, kala azar and liver disease without concomitant rheumatoid arthritis. Ultracentrifugation of sera from these patients revealed the presence of a heavy gamma globulin resembling rheumatoid factor. Amboceptor‐sensitized sheep cell tests were uniformly negative except in the one case of liver disease.