Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
- 22 May 2008
- journal article
- Published by Taylor & Francis in Autophagy
- Vol. 4 (5), 659-668
- https://doi.org/10.4161/auto.6058
Abstract
Autophagy has been reported to be increased in irradiated cancer cells resistant to various apoptotic stimuli. We therefore hypothesized that induction of autophagy via mTOR inhibition enhances rad...Keywords
This publication has 61 references indexed in Scilit:
- Autophagy and Cell DeathCurrent Topics in Developmental Biology, 2007
- Autophagy for Cancer Therapy through Inhibition of Pro-apoptotic Proteins and Mammalian Target of Rapamycin SignalingJournal of Biological Chemistry, 2006
- Deficiency in Apoptotic Effectors BAX and BAK Reveals an Autophagic Cell Death Pathway Initiated by Photodamage to the Endoplasmic ReticulumAutophagy, 2006
- AutophagyAnnals of the New York Academy of Sciences, 2006
- Increased Sensitivity to Cisplatin in Non-Small Cell Lung Cancer Cell Lines after FHIT Gene TransferNeoplasia, 2006
- Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factorNature Medicine, 2002
- Clinical Implications of Circulating Angiogenic Factors in Cancer PatientsJournal of Clinical Oncology, 2001
- A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.2001
- Adenoviral Bak overexpression mediates caspase-dependent tumor killing.2000
- Mechanism and regulation of lysosomal sequestration and proteolysis.1991