Confirmation of F13A assignment and sequence information concerning F13A‐HLA‐GLO

Abstract

The polymorphism of the blood clotting factor 13A was examined in some of the Danish material of normal families. A total of 4 alleles were recognized, with allele frequencies as follows: F13A*1 = 0.817, F13A*2 = 0.177, F13A*4 = 0.003 and a new allele F13A* 5 = 0.003. The distribution of unrelated individuals did not deviate significantly from the Hardy-Weinberg expectation. Linkage of F13A with HLA was confirmed (.cxa.z = 5.18, .cxa..theta. = 0.17 in males and .cxa.z = 0.14, .cxa..theta. = 0.37 in females). The sequence of the 3 systems F13A, HLA and GLO [glyoxalase] was found to be F13A-HLA-GLO as judged from 2 families each with a recombinant within the HLA system in males.