Acyclic Nucleosides other than Acyclovir as Potential Antiviral Agents
- 1 July 1985
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 4 (3), 411-427
- https://doi.org/10.1080/07328318508056172
Abstract
In the past few years interest in the synthesis and biological properties of acyclic nucleosides has been generated based largely upon the development of acyclovir [9-[(2-hydroxyethoxy)methyll guanine, 1a] as an antiviral agent for the treatment of certain herpesvirus infections. The literature in the area covers a variety of different heterocycles, a variety of different side chains, and spans research that is strictly synthetic to research that is strictly biological. Two compounds, 9-[(2-hydroxy-l-(hydroxymethyl)ethoxy)methyl] guanine (1b) and 9-(S)-(2,3-dihydroxypropyl)adenine (2), have received the most attention, but many others have been made.Keywords
This publication has 94 references indexed in Scilit:
- A comparison of the antiviral agents 2′-nor-2′-deoxyguanosine and acyclovir: Uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphatesBiochemical and Biophysical Research Communications, 1983
- Adenosine deaminase inhibitors. Synthesis and biological evaluation of (.+-.)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d][1,3]diazepin-8-ol and some selected C-5 homologs of pentostatinJournal of Medicinal Chemistry, 1983
- Conversion of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine to acyclovir as catalyzed by adenosine deaminaseBiochemical Pharmacology, 1983
- INSECT STERILITY INDUCED BY A BROAD‐SPECTRUM ANTIVIRAL AGENT (S)‐9‐(2,3‐DIHYDROXYPROPYL) ADENINEEntomologia Experimentalis et Applicata, 1983
- Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)Biochemical and Biophysical Research Communications, 1982
- Purine acyclic nucleosides. Nitrogen isosteres of 9-[(2-hydroxyethoxy)methyl] guanine as candidate antiviralsJournal of Medicinal Chemistry, 1981
- Inhibitory effect of a broad-spectrum antiviral egent, (S)-9-(2,3-dihydroxypropyl)adenine, on spermatogenesis in miceToxicology and Applied Pharmacology, 1981
- Pyrimidine acyclic nucleosides. 5-Substituted 1-[(2-aminoethoxy)methyl]uracils as candidate antiviralsJournal of Medicinal Chemistry, 1981
- 9‐(S)‐(2,3‐Dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with rous sarcoma virusFEBS Letters, 1979
- Synthesis of N-(2,3-dihydroxypropyl) derivatives of heterocyclic basesCollection of Czechoslovak Chemical Communications, 1978