Ionic effect on intestinal transport of glucose in the rat

Abstract

A loop of upper jejunum of anesthetized rats was perfused in situ with glucose (500 mg/l.) dissolved in either isosmotic Na₂SO₄, Li₂SO₄, K₂SO₄ or MgSO₄. Rapid glucose absorption takes place from the Na₂SO₄ solution, whereas the glucose transport is inhibited if Na is replaced. The rate of inhibition varied: 91% with Li, 86% with K and 75% with Mg. The inhibition is reversible by the subsequent perfusion of the same gut with Na₂SO₄.