Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load
Open Access
- 13 August 2013
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 36 (9), 2530-2535
- https://doi.org/10.2337/dc12-2221
Abstract
OBJECTIVE: Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have metabolic effects in animal models. However, the relevance of these findings to human subjects is not clear. We evaluated the acute effects of sucralose ingestion on the metabolic response to an oral glucose load in obese subjects. RESEARCH DESIGN AND METHODS: Seventeen obese subjects (BMI 42.3 ± 1.6 kg/m2) who did not use NNS and were insulin sensitive (based on a homeostasis model assessment of insulin resistance score ≤2.6) underwent a 5-h modified oral glucose tolerance test on two separate occasions preceded by consuming either sucralose (experimental condition) or water (control condition) 10 min before the glucose load in a randomized crossover design. Indices of β-cell function, insulin sensitivity (SI), and insulin clearance rates were estimated by using minimal models of glucose, insulin, and C-peptide kinetics. RESULTS: Compared with the control condition, sucralose ingestion caused 1) a greater incremental increase in peak plasma glucose concentrations (4.2 ± 0.2 vs. 4.8 ± 0.3 mmol/L; P = 0.03), 2) a 20 ± 8% greater incremental increase in insulin area under the curve (AUC) (P < 0.03), 3) a 22 ± 7% greater peak insulin secretion rate (P < 0.02), 4) a 7 ± 4% decrease in insulin clearance (P = 0.04), and 5) a 23 ± 20% decrease in SI (P = 0.01). There were no significant differences between conditions in active glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide, glucagon incremental AUC, or indices of the sensitivity of the β-cell response to glucose. CONCLUSIONS: These data demonstrate that sucralose affects the glycemic and insulin responses to an oral glucose load in obese people who do not normally consume NNS.Keywords
This publication has 33 references indexed in Scilit:
- Effects of Diet Soda on Gut Hormones in Youths With DiabetesDiabetes Care, 2012
- Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretionProceedings of the National Academy of Sciences, 2012
- Banting Lecture 2011Diabetes, 2011
- Analysis of glucagon-like peptide 1; what to measure?Clinica Chimica Acta; International Journal of Clinical Chemistry, 2011
- Ingestion of Diet Soda Before a Glucose Load Augments Glucagon-Like Peptide-1 SecretionDiabetes Care, 2009
- Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin SecretionPLOS ONE, 2009
- Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjectsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2009
- Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1Proceedings of the National Academy of Sciences, 2007
- T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1Proceedings of the National Academy of Sciences, 2007
- Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2The Journal of Physiology, 2007