Key antigenic determinants in regulation of the immune response.
- 1 September 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (9), 3984-3987
- https://doi.org/10.1073/pnas.74.9.3984
Abstract
The [mouse] immune response to .beta.-galactosidase (.beta.-D-galactoside galactohydrolase; EC 3.2.1.23) is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A CNBr peptide of .beta.-galactosidase, CB2, mimics the suppression seen with the enzyme. It is time dependent, carrier specific and anti-.theta. sensitive; however, this suppression is not preceded by a wave of help. It is possible that CB2 cannot stimulate helpers, and is only able to activate suppressor cells. One small region of an antigen, capable of activating suppressors, can apparently nullify the positive effect induced in helper T [thymus-derived] cells reactive with other epitopes on .beta.-galactosidase. Key determinants on macromolecules may be influential in regulating the immune response to the entire antigen molecule.This publication has 20 references indexed in Scilit:
- Differential function of major histocompatibility complex antigens in T-lymphocyte activationNature, 1976
- Properties of Primed Suppressor T Cells and their ProductsImmunological Reviews, 1975
- Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell interactions to determinants linked together: suppression vs. enhancement.The Journal of Experimental Medicine, 1975
- Genetic control of immune responses in vitro. VI. Experimental conditions for the development of helper T-cell activity specific for the terpolymer L-glutamic aicd60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice.The Journal of Experimental Medicine, 1975
- Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.The Journal of Experimental Medicine, 1975
- Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.The Journal of Experimental Medicine, 1975
- H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.The Journal of Experimental Medicine, 1975
- Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein.1975
- The suppressive effect of carrier priming on the response to a hapten‐carrier conjugateEuropean Journal of Immunology, 1974
- Immunoglobulin determinants on the lymphocytes of normal rabbits. 3. As4 and As6 determinants on individual lymphocytes and the concept of allelic exclusion.1971