Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review
- 13 February 2014
- journal article
- case report
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 41 (4), 370-379
- https://doi.org/10.1111/cup.12293
Abstract
A 62-year-old male presented with a 10-day history of a diffuse, erythematous papular rash sparing the palms and soles. Histopathologic examination of a skin lesion showed loose non-caseating granulomas in a lymphoplasmacytic background. Scattered spirochetes were identified by Treponema pallidum immunohistochemistry, in keeping with a diagnosis of secondary syphilis. Granulomatous inflammation in secondary syphilis is uncommon. A review of the literature reveals that the majority of prior reported cases of granulomatous secondary syphilis share similar characteristics to this case; namely, a papular or nodular clinical presentation, sparing of the palms and soles, and collections of epithelioid histiocytes with associated lymphocytes and variable numbers of plasma cells.Keywords
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