THE REVERSIBLE INACTIVATION OF PROTHROMBIN: A FACTOR RESPONSIBLE FOR ITS PARTIAL REACTIVATION

Abstract

The restoration of prothrombin activity to stored plasma, and similar prepns., by aluminum hydroxide plasma or dicumarol plasma cannot be explained on the basis of a change in the reactivity of nbrinogen. It is suggested that this inactivation of prothrombin is the result of inactivation of a labile group in the prothrombin molecule. This group can be reactivated by other proteins present in plasma and serum.