Distribution of dissociation constant values of muscarinic agonists
- 1 February 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 41 (2), 134-135
- https://doi.org/10.1111/j.2042-7158.1989.tb06411.x
Abstract
The frequency distributions of dissociation constant values of some muscarinic agonists (carbachol, muscarone and cis-2-methyl-5-trimethylammoniummethyl-1,3-oxathiolane) obtained on guinea-pig ileum and atria and rat urinary bladder have been examined to see if the means of the dissociation constant values and the statistical tests for their significance, should be based on geometric rather than on arithmetic means. For the three compounds the distributions on a logarithmic scale did not significantly deviate from normality while the distributions on an arithmetic scale tended to deviate from normality.This publication has 4 references indexed in Scilit:
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- Comparative studies of the postjunctional activities of some very potent muscarinic agonistsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1986
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- COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*Annals of the New York Academy of Sciences, 1967