Predicting the carcinogenicity of the aromatic amine derivatives tested in the second UKEMS collaborative study

Abstract

The carcinogenicity prediction and battery selection (CPBS) procedure was used to analyze the short-term in vitro and in vivo genotoxicity results obtained during the Second UKEMS Collaborative Study. In accordance with preliminary animal bioassay results, CPBS predicted correctly the carcinogenicity of benzidine, 4,4″-diaminoterphenyl and 4-dimethylaminoazobenzene. CPBS predicted the non-carcino-genkity of 4-cyanodimethylaniline, a chemical of as yet unknown carcinogenicity. Moreover, CPBS indicated that for the chemicals included in the UKEMS study, highly predictive as well as cost-effective batteries consisting of three short-term assays could be identified.