Aspartame-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 7 (5), 605-619
- https://doi.org/10.3109/03639048109057733
Abstract
Differential scanning calorimetry was used as a screening technique for assessing the compatibility of Aspartame with some of the currently available direct compression excipients. AsDartame was found to be compatible with Avicel PH 101, Avicel PH 105, Elcema F 150, Elcema G 250, Sta-Rx 1500, Cab-O-Sil, Sorbitol, Di-Pac and Brownex Sugar, while incompatible with dicalcium phosphate dihydrate. It appears that stearic acid can be used as a lubricant in formulations containing Aspartame while magnesium stearate cannot.Keywords
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