FACTOR-VIII COAGULANT ANTIGEN IN HEMOPHILIC PLASMA - A COMPARISON OF 5 ALLOANTIBODIES
- 1 January 1980
- journal article
- research article
- Vol. 56 (4), 615-619
Abstract
Five independent alloantibodies directed to factor VIII coagulant antigen (VIII:CAg) were assessed against normal, von Willebrand''s disease [vWd] and severe hemophilia A plasmas. Immunoradiometric assays (IRMA) were developed for each antibody, one of which had arisen spontaneously and four in transfused hemophiliacs. The correlations between assays were very high for normal, vWd, and both CRM+ [cross-reacting material] and CRM- hemophiliacs. IRMA may be developed from almost any reasonably high titered alloantibody and used with confidence in diagnosing CRM- hemophilia A in utero by fetoscopy.This publication has 8 references indexed in Scilit:
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