Synthesis of 2′-O-p-Nitrophenylethylsulfonyl-Ribonucleosides
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 6 (1-2), 505-507
- https://doi.org/10.1080/07328318708056270
Abstract
The appropriate protection of the 2′-OH group in ribonucleosides is the crucial point of oligoribonucleotide synthesis. The use of the tetrahydropyranyl (1), 4-methoxytetrahydropyranyl (2), tert. butyldimethylsily1 (3) and o-nitrobenzyl group (4) respectively has its limitations in the acid sensitivity or the problems arising during the deprotection steps. A more stable blocking group is needed, which is stable towards acid and base treatment but can be cleaved selectively under different conditions.Keywords
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