Serotonin and gender-specific psychiatric disorders
- 1 January 1997
- journal article
- Published by Taylor & Francis in International Journal of Psychiatry in Clinical Practice
- Vol. 1 (1), 3-13
- https://doi.org/10.3109/13651509709069200
Abstract
The serotonergic system has been linked to the etiology of several, albeit disparate, psychiatric disorders. The accumulation of many lines of evidence support the view that there are gender differences in the serotonergic system in humans. It is further proposed that a gender differentiated serotonergic system acts as the nidus for the development of gender-specific psychiatric disorders. Depression, anxiety and eating disorders are largely seen in females, whereas alcoholism, aggressivity and suicide predominate in males. Evidence from both animal and human studies suggesting that the serotonergic system mediates between social-environmental experience and biological states is presented and reviewed. A reconceptualization of the serotonergic system as a gender-specific psychobiological interface is proposed. (Int J Psych Clin Prac 1997; 1: 3–13)Keywords
This publication has 150 references indexed in Scilit:
- Brain Serotonin, Carbohydrate‐Craving, Obesity and DepressionObesity Research, 1995
- Serotonin Receptors: Genetic insights into serotonin functionCurrent Biology, 1995
- Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publicationLife Sciences, 1995
- Neuroendocrine probes of serotonergic function: A critical reviewLife Sciences, 1993
- Endocrine and receptor pharmacology of serotonergic anxiolytics, antipsychotics and antidepressantsLife Sciences, 1992
- Rat brain serotonin: Biochemical and functional evidence for a sex differenceJournal of Neural Transmission, 1985
- Sex steroid modulation of the serotonin behavioral syndromeLife Sciences, 1984
- Plasma prolactin changes following fenfluramine in depressed patients compared to controls: An evaluation of central serotonergic responsibility in depressionLife Sciences, 1984
- Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behaviorLife Sciences, 1983
- Seasonal variations in biochemical factors related to depressive illnessJournal of Affective Disorders, 1980