COMPARISON BETWEEN THE EARLY CHANGES IN ISONIAZID INTOXICATION AND THE CHROMATOLYTIC RESPONSE TO NERVE LIGATION IN SPINAL GANGLION CELLS OF THE RAT
- 1 November 1981
- journal article
- research article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 7 (6), 489-501
- https://doi.org/10.1111/j.1365-2990.1981.tb00248.x
Abstract
The early effects of acute isoniazid [INH] intoxication and the early responses of the neuron to axotomy were compared in lumbar spinal ganglion cells in the rat. The cells were studied by light microscopy and EM during the 4 days after a single oral dose (2 g/kg) is isoniazid and for 4 days after application of a tight ligature to the sciatic nerve at the level of the sciatic notch. After axotomy a greater proportion of cells showed changes visible by light microscopy and EM than after INH. Small dark neurons were affected more rapidly and more severely by both insults than the large light cells, as evidenced principally by changes in their ribosomal organization. Large light cells showed little response to INH. The 1st response to axotomy was visible .apprx. 12 h after injury. The response to INH began 24 h after the single oral dose. The early cell responses to INH therefore apparently precede axon degeneration which is first seen 72 h later and are probably a direct toxic effect.This publication has 12 references indexed in Scilit:
- MECHANISMS INVOLVED IN THE ‘DYING-BACK’ PROCESS—AN HYPOTHESIS IMPLICATING COENZYMESNeuropathology and Applied Neurobiology, 1977
- Vascular leakage in the dorsal root ganglia of the rat, studied with horseradish peroxidaseJournal of the Neurological Sciences, 1976
- THE EFFECT OF CHRONIC DOSING WITH MERCURIC CHLORIDE ON DORSAL ROOT AND TRIGEMINAL GANGLIA OF RATSNeuropathology and Applied Neurobiology, 1975
- THE PENETRATION OF DAPSONE, RIFAMPICIN, ISONIAZID AND PYRAZINAMIDE INTO PERIPHERAL NERVESBritish Journal of Pharmacology, 1975
- ULTRASTRUCTURAL CHANGES IN THE DORSAL ROOT AND TRIGEMINAL GANGLIA OF RATS POISONED WITH METHYL MERCURYNeuropathology and Applied Neurobiology, 1975
- Observations on the nucleolar and total cell body nucleic acid of injured nerve cellsThe Journal of Physiology, 1968
- A STUDY OF CHROMATOLYSIS IN DORSAL ROOT GANGLIA AT THE CELLULAR LEVELJournal of Neuropathology and Experimental Neurology, 1964
- Investigations on the ultrastructural changes of the spinal ganglion neurons in the course of axon regeneration and cell hypertrophyCell and tissue research, 1963
- Investigations on the ultrastructural changes of the spinal ganglion neurons in the course of axon regeneration and cell hypertrophyCell and tissue research, 1963