Bladder Cancer Induction by Aromatic Amines: Role of N -Hydroxy Metabolites
- 13 February 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3920), 992-993
- https://doi.org/10.1126/science.167.3920.992
Abstract
Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.Keywords
This publication has 1 reference indexed in Scilit:
- N-hydroxylation of 1-naphthylamine in the dogLife Sciences, 1967