Observations on the anti-anaphylactic activity of hydrocortisone and related steroids

Abstract

Hydrocortisone and some synthetic analogues had negligible anti-anaphylactic activity in actively sensitised guinea-pigs when administered alone but they potentiated the protection afforded by mepyramine. Hydrocortisone did not affect the yield of histamine from sensitised guinea-pig lung subjected to anaphylaxis in vitro but reduced the amount of srs-a produced under these conditions.