Formation of the COOH‐terminal amide group of thyrotropin‐releasing‐factor
- 21 February 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 152 (2), 277-281
- https://doi.org/10.1016/0014-5793(83)80395-0
Abstract
The precursors of peptide hormones that possess a COOH‐terminal α‐amide group contain a glycine residue following the amino acid which is amidated in the hormone. 〈Glu—His—Pro—Gly was synthesized as a putative precursor of thyroliberin. Bovine pituitary neurosecretory granules were shown to contain an amide group‐forming activity associated with an M r of about 62000 protein(s) which converts the tetrapeptide to thyroliberin.Keywords
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