Frequency of Reduced Vancomycin Susceptibility and Heterogeneous Subpopulation in Persistent or Recurrent Methicillin-Resistant Staphylococcus aureus Bacteremia
- 1 May 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 38 (9), 1328-1330
- https://doi.org/10.1086/383036
Abstract
Vancomycin susceptibility was checked in isolates from initial and final blood samples obtained from 22 patients with persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia. The minimum inhibitory concentration of vancomycin was determined using Etest and found to have increased in 2 pairs of isolates, and results of screening in 4 µg vancomycin and a modified population analysis profile suggested heteroresistance in 3 isolates (13.6%). Heteroresistance is not a common cause of persistent or recurrent bacteremia.Keywords
This publication has 10 references indexed in Scilit:
- Clinical Implications of Varying Degrees of Vancomycin Susceptilibity in Methicillin-ResistantStaphylococcus aureusBacteremia1Emerging Infectious Diseases, 2003
- Evolution of a Vancomycin-Intermediate Staphylococcus aureus Strain In Vivo: Multiple Changes in the Antibiotic Resistance Phenotypes of a Single Lineage of Methicillin-Resistant S . aureus under the Impact of Antibiotics Administered for ChemotherapyJournal of Clinical Microbiology, 2003
- Staphylococcus aureusAccessory Gene Regulator(agr)Group II: Is There a Relationship to the Development of Intermediate‐Level Glycopeptide Resistance?The Journal of Infectious Diseases, 2003
- Evidence for a Continuum of Decreased Vancomycin Susceptibility in UnselectedStaphylococcus aureusClinical IsolatesThe Journal of Infectious Diseases, 2002
- Vancomycin Susceptibility of Oxacillin-Resistant Staphylococcus aureus Isolates Causing Nosocomial Bloodstream InfectionsJournal of Clinical Microbiology, 2002
- Laboratory Reporting of Staphylococcus aureus with Reduced Susceptibility to Vancomycin in United States Department of Veterans Affairs Facilities1Emerging Infectious Diseases, 2002
- Molecular Analysis of Coagulase‐NegativeStaphylococcusIsolates from Blood Cultures: Prevalence of Genotypic Variation and Polyclonal BacteremiaClinical Infectious Diseases, 2001
- A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospitalJournal of Antimicrobial Chemotherapy, 2001
- Twenty months of screening for glycopeptide-intermediateStaphylococcus aureusJournal of Antimicrobial Chemotherapy, 2000
- Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibilityJournal of Antimicrobial Chemotherapy, 1997