INTRACELLULAR FLUID LOSS IN HEMORRHAGE

Abstract

Dogs were kept on a fasting regime, the daily output in the urine of Na, Cl. K and N being detd. After a basal level of excretion was reached, hemorrhage to the extent of 2 to 3% of body weight was produced, the observations on the urine then being continued. A sharp increase in the amt. of K eliminated in the urine during the 24 hrs. after hemorrhage was noted, without a corresponding increase in N of urine. This increase in excretion of K was shown to be unrelated to water drinking and was associated with a sharp rise in the K/N ratio in the urine. The authors conclude that fluid is abstracted from the cells as well as the interstitial areas in maintenance of plasma volume immediately after hemorrhage. The principle of parallel movement of water and base in the tissues forms the basis of the experimental plan.