CALCIUM AND PHOSPHORUS METABOLISM IN A VERIFIED CASE OF PITUITARY BASOPHILISM
- 1 August 1936
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 58 (2), 213-228
- https://doi.org/10.1001/archinte.1936.00170120029002
Abstract
Patients with pituitary basophilism commonly have generalized demineralization of the skeleton. In some cases this is so severe that multiple fractures occur. The cause of this skeletal abnormality has been obscure. Cushing1 suggested that the parathyroid bodies might be activated to excessive secretion by the pituitary lesion and thus cause the osteoporosis. In the majority of verified cases of pituitary basophilism the parathyroid glands when examined post mortem are described as being normal, fatty or atrophic. In several cases the parathyroid glands were enlarged but were found to be grossly infiltrated with fat, which contributed to their size. In only one case has a parathyroid adenoma been found.2 Only in the case described in 1912 by Schmorl3 and later by Molineus4 has hyperplasia of the parathyroid glands been observed. The patient exhibited the clinical syndrome of pituitary basophilism and at postmortem examination was found to have a large basophil adenomaThis publication has 3 references indexed in Scilit:
- PITUITARY BASOPHILISM REPORT OF A CASEThe Lancet, 1947
- STUDIES OF CALCIUM AND PHOSPHORUS METABOLISMJCI Insight, 1929
- STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM 1JCI Insight, 1929