CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study
- 23 August 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 112 (8), 1113-1120
- https://doi.org/10.1161/circulationaha.105.543579
Abstract
Background— Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. Methods and Results— We analyzed the association of genetic variation in the MCP-1 gene (CCL2) with prevalent myocardial infarction and serum MCP-1 levels in the community-based Framingham Heart Study Offspring Cohort (50% women; mean age, 62 years). MCP-1 levels and CCL2 genotypes were determined in 3236 and 1797 individuals, respectively. Significant clinical correlates of MCP-1 levels were age, cigarette smoking, triglycerides, body mass index, and waist-to-hip ratio. The MCP-1-2578G allele located in the CCL2 regulatory region was significantly associated with both higher serum MCP-1 levels in a recessive genetic model (358±10 versus 328±3 pg/mL; P=0.002) and higher prevalence of myocardial infarction in a dominant genetic model (adjusted odds ratio, 2.0; 95% CI, 1.2 to 3.3; P=0.005). We also defined the linkage disequilib...Keywords
This publication has 35 references indexed in Scilit:
- Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: Evidence for susceptibility loci on 1qAtherosclerosis, 2005
- Atherosclerosis in Patients Infected With HIV Is Influenced by a Mutant Monocyte Chemoattractant Protein-1 AlleleCirculation, 2004
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosisEuropean Heart Journal, 2004
- Short Communication The MCP-1 Promoter -2518 Polymorphism in Behcet's Disease: Correlation Between Allele Types, MCP-1 Production and Clinical Symptoms among Korean PatientsAutoimmunity, 2004
- The Structure of Haplotype Blocks in the Human GenomeScience, 2002
- Monocyte Chemoattractant Protein-1 Induces Proliferation and Interleukin-6 Production in Human Smooth Muscle Cells by Differential Activation of Nuclear Factor-κB and Activator Protein-1Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Monocyte chemoattractant protein‐1 and coronary artery diseaseClinical Cardiology, 2002
- Score Tests for Association between Traits and Haplotypes when Linkage Phase Is AmbiguousAmerican Journal of Human Genetics, 2002
- A Novel Polymorphism in the MCP-1 Gene Regulatory Region That Influences MCP-1 ExpressionBiochemical and Biophysical Research Communications, 1999