Pemphigus-Like IgA Deposits and Vesiculo-Pustular Dermatosis in a 10-Year-Old Girl

Abstract
Pemphigus-like IgA deposits have been found to be associated with a recurrent pustular eruption in an adult reported as: ‘Intraepidermal neutrophilic IgA dermatosis’. We report here the case of a 10-year-old girl affected with recurrent crops of antibiotic-resistant, inpetigo-like, dermatosis of the scalp and body associated with (1) blood eosinophilia (up to 1,750/mm3); (2) up to 90% eosinophils in Tzanck’s smears; (3) histological picture of neutrophilic spongiosis; (4) IgA) deposits in a pemphigus-like pattern in both lesional and nonlesional skin, and (5) no IgA antibodies to epidermal antigens detectable in the serum either by indirect immunofluorescence or Western blot. The case does not fulfill the diagnostic criteria for other eosinophilic and/or neutrophilic dermatoses, including intraepidermal neutrophilic IgA dermatosis, and suggests that the spectrum of skin diseases associated with pemphigus-like IgA deposits remains to be clarified.