Urinary Excretion of DDA Following Ingestion of DDT and DDT Metabolites in Man

Abstract

Oral doses of DDT (5, 10, 20 mg/day) DDE, DDD, and DDA (5 mg/day) administered to human volunteers are, in part, excreted as DDA in the following order: DDA>DDD>DDT. Ingestion of DDE failed to produce any increase of DDA excretion. Increased urinary DDA excretion is detectible within 24 hours of DDT, DDD, or DDA ingestion. DDA excretion returns to predose levels within two to three days of dose termination for DDA but continues significantly above predose levels for over four months following termination of DDD or DDT doses.