QUANTITATION OF HUMAN THYMUS-LEUKEMIA-ASSOCIATED ANTIGEN BY RADIOIMMUNOASSAY IN DIFFERENT FORMS OF LEUKEMIA

Abstract

Using a radioimmunoassay, increased levels of a human thymus/leukemia-associated antigen (HThy-L) were detected in leukemic cells and plasma from most patients with E[erythrocyte]-rosette-positive acute lymphoblastic leukemia (ALL) and a number of patients with E-rosette-negative ALL, acute myeloblastic leukemia (AML), acute monomyelocytic leukemia (AMML) and acute undifferentiated leukemia (AVL). Low levels of HThy-L were demonstrated in white cells from patients with chronic myelocytic leukemia (stable phase) and in mononuclear cells from patients with chronic lymphatic leukemia. The relationship between HThy-L and differentiation of hematopoietic cells was discussed.